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Researchers
at The Feinstein Institute for Medical Research have discovered that a bean
commonly used in Chinese cuisine protects against the life-threatening
condition sepsis.
It
has been found that a deoxyribonucleic acid (DNA) protein, HMGB1, mediates
inflammation. Inflammation is necessary for maintaining good health – without
inflammation, wounds and infections would never heal. However, persistent and
constant inflammation can damage tissue and organs, and lead to diseases such
as sepsis.
Sepsis
is a potentially life-threatening complication of an infection or injury, and
occurs when chemicals released into the bloodstream to fight the infection
trigger inflammation throughout the body. The result is that organs become
damaged, including liver, heart, lungs, kidney, and brain. If excessive damage
occurs, it may be irreversible. Therefore, it is important to identify ways in
which persistent and constant inflammation can be halted.
Neutralizing
the protein HMGB1 protects against persistent and constant inflammation that
results in damage to tissue and organs. Haichao Wang, PhD, and his colleagues,
including Shu Zhu, MD and PhD, and Andrew E. Sama, MD, at the Feinstein
Institute found that extract from mung bean (Vigna radiata), a bean native to
India and commonly used in Chinese food and traditional medicine, reduced the
release of HMGB1, thereby increasing survival rates in mice from 29.4 percent
to 70 percent (P < 0.05).
“Many
traditional medicinal herbs have been successfully developed into effective
therapies for various inflammatory ailments, and now we have validated the
therapeutic potential of another medicinal product, mung bean extract,” said
Dr. Wang. “Demonstrating that mung bean extract has a positive effect on septic
mice shows promise that this bean can also have a positive effect on septic
humans – of course, additional studies are required to prove the safe and
effective use in humans.”
###
The
above story is based on the Octiber 26, 2012 news release by North Shore-Long
Island Jewish (LIJ) Health System.
These
findings are published in the current issue of Evidence-based Complementary and
Alternative Medicine (eCAM):
Shu
Zhu, Wei Li, Jianhua Li, Arvin Jundoria, Andrew E. Sama, Haichao Wang. It Is
Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against
Sepsis. Evid. Based Complement. Alternat.
Med., 2012; 2012: 1 DOI: 10.1155/2012/498467
Click HERE to read the full
text online.
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