Statins inhibit the synthesis of cholesterol by reducing the production of mevalonate, a precursor of both cholesterol and coenzyme Q10. Since both cholesterol and coenzyme Q10 are produced by the same pathway, it is not surprising that statins have been reported to reduce serum and muscle coenzyme Q10 levels. Coenzyme Q10, also known as coenzyme Q, ubidecarenone, and ubiquinone, is found in all human cells, with the highest concentrations in the heart, liver, kidney, and pancreas. It is a potent antioxidant, a membrane stabilizer, and an integral cofactor in the mitochondrial respiratory chain, helping to generate adenosine triphosphate, the major cellular energy source. It may also regulate genes associated with cell metabolism.
Taking CoQ10 supplements can correct the deficiency caused by statin medications without affecting the medication's positive effects on cholesterol levels.
The recommended adult dose for CoQ10 supplementation is 30 - 200 mg daily. CoQ10 is fat-soluble so should be taken with a meal containing fat for optimal absorption. Also, taking CoQ10 at night may help with the body's ability to use it.
Journal Reference Wyman M, Leonard M, Morledge T. Coenzyme Q10: a therapy for hypertension and statin-induced myalgia? Cleveland Clinic Journal of Medicine. 2010 Jul;77(7):435-42.
Coenzyme Q10 has been used to prevent and treat statin myopathy; however, clinical trial evidence demonstrating their efficacy is limited. If you have muscle aches or other troubling symptoms after starting statin medications, talk to your doctor as soon as possible.
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