Wednesday, November 7, 2012

Dukong Anak and Liver Cancer


The annual herb Phyllanthus niruri is best known by the common names Stonebreaker or Seed-Under-Leaf (Eng.), Chanca Piedra (Sp.), Bhumyamalaki in Ayurveda, and Quebra Pedra (Port.), but has many other common names in assorted languages, including dukong anak, dukong-dukong anak, amin buah, rami buah, turi hutan, bhuiaonla, Meniran (Indonesia), കീഴാനെല്ലി (Malayalam) and கீழாநெல்லி / Keela Nelli (Tamil). The herb is known as Nela Nelli in Kannada and Nela Usiri in Telugu.

Anti-tumor Activity of Phyllanthus niruri

Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemopreventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as chemopreventive agents. 

Phyllanthus niruri is a well known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral, antibacterial, analgesic, antispasmodic and antidiabetic (1). 

PK Goyal and colleagues at the Radiation & Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, India (2) recently concluded a study to evaluate the anti-tumor activity of a
hydro-alcoholic extract of the whole plant, in 7-9 week old male Swiss albino mice, on the two stage process of skin carcinogenesis induced by a single topical application of 7, 12-dimethylbenz (a)anthracene (100μg/100μl acetone) and two weeks later promoted by repeated application of croton oil (1% in acetone/three times a week) till the end of experiment (16 weeks). The oral administration of P. niruri at a dose of 1000 mg/kg/b.wt. at peri- (i.e. 7 days before & 7 days after DMBA application) and post- (i.e. starting from the croton oil application) initiational phase of papillomagenesis caused significant reduction in tumor incidence, tumor yield, tumor burden and cumulative number of papillomas as compared to carcinogen-treated controls. Furthermore, the average latent period was significantly increased in the PNE treated group.                                                                                                                                         

The results thus suggest that P. niruri extract exhibits significant anti-tumor activity, which supports the traditional medicinal utilization of this plant.


1. Paithankar VV, Raut KS, Charde RM, Vyas JV. Phyllanthus Niruri: A magic Herb. Research in Pharmacy 1(4) : 1-9, 2011

You can read the full text HERE

2. Priyanka Sharma, Jyoti Parmar, Preeti Verma, Priyanka Sharma, PK Goyal. Anti-tumor Activity of Phyllanthus niruri (a Medicinal Plant) on Chemical-induced Skin Carcinogenesis in Mice.  Asian Pacific J Cancer Prev, 10, 1089-1094
You can read the full text HERE 

Hepar-P contains 250mg standardisded extract of Phyllanthus niruri per capsule and is patent-protected. Recommended dosage is 2 capsules, 2 to 3 times daily.

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