Credit: medscape.com |
Statins and
Exercise, Independently Beneficial, Even Better In Combination
Statins are commonly prescribed for management of dyslipidaemia and
cardiovascular disease. Increased fitness is also associated with low mortality
and is recommended as an essential part of promoting health. However, little
information exists about the combined effects of fitness and statin treatment
on all-cause mortality.
Now a new study offers fresh evidence that the two appear to be
independently beneficial, and that adding the two together may result in
greater benefits than either alone.
In the prospective cohort study, Peter F Kokkinos and colleagues assessed
10 043 veterans with dyslipidemia (mean age 58.8 years) from VA medical centers
in Palo Alto, CA and Washington DC who had an exercise tolerance test between
1986 and 2011.
Individuals were assigned to one of four fitness categories based on METs
achieved during exercise testing and eight categories based on fitness status
and statin treatment. The primary end point was all-cause mortality adjusted
for age, body-mass index, ethnic origin, sex, history of cardiovascular
disease, cardiovascular drugs, and cardiovascular risk factors. They
ascertained mortality from VA records on December 31, 2011.
During a median follow-up of 10 years, 2318 participants died. Mortality
risk was 18.5% in people taking statins versus 27.7% in those not taking
statins.
Statins With Better
Physical Fitness Can Boost Survival
In patients who took statins, risk of death decreased as fitness
increased.
Highly Fit Not on
Statins Had Lower Mortality Than Unfit on Statins
Strikingly, the study found that patients not prescribed statins but who
were highly fit still had a significantly lower risk of mortality than those
taking statins who were unfit.
This study reinforces the importance of physical activity for individuals
with dyslipidaemia.
###
Kokkinos PF, Faselis C, Myers J, et al. Interactive effects of fitness
and statin treatment on mortality risk in veterans with dyslipidemia: a cohort
study. Lancet 2012; DOI: 10.1016/S0140-6736(12)61426-3.
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