Credit: media2.intoday.in |
The Seasonality of Influenza
Influenza, commonly known as the flu, has distinct
transmission patterns around the world. In temperate regions, influenza’s
occurrence peaks during the winter season, while in some tropical regions, the
disease’s occurrence tends to correspond with the rainy season.
A recent study by Linsey Marr et al presents for the first
time the relationship between the influenza A virus viability in human mucus
and humidity over a large range of relative humidities, from 17 percent to 100
percent. They found the viability of the flu A virus was highest when the
relative humidity was either close to 100 percent or below 50 percent. The
results in human mucus may help explain influenza’s seasonality in different
regions.
At low humidity, respiratory droplets evaporate completely
and the virus survives well under dry conditions. But at moderate humidity, the
droplets evaporate some, but not completely, leaving the virus exposed to higher
levels of chemicals in the fluid and compromising the virus’ ability to infect
cells.
In a past study the researchers collected samples from a
waiting room of a health care center, two toddlers’ rooms and one babies’ area
of a daycare center, as well as three cross-country flights. Findings showed
the average concentration was 16,000 viruses per cubic meter of air, and the
majority of the viruses were associated with fine particles, less than 2.5
micrometers, which can remain suspended for hours.
Possible explanations for the seasonality of the flu have
been investigated, such as the return of kids to school, people spending more
time indoors in the winter, and lower light levels that affect the immune
system, but there is no agreement on them, said the NSF CAREER award recipient.
The researchers found humidity could explain the seasonality
of influenza by controlling the ability of viruses to remain infectious while
they are in droplets or aerosols. The viruses survived best at low humidity,
such as those found indoors in the winter, and at extremely high humidity.
Humidity affects the composition of the fluid, namely the concentrations of salts
and proteins in respiratory droplets, and this affects the survival rates of
the flu virus.
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