Credit: www.prostatecancer-infoguide.com |
Obesity Promotes Prostate Cancer by
altering gene regulation
Prostate
cancer is one of the most common cancers in men and early treatment is usually
very successful. However, like other cancers, obesity increases the risk of
aggressive prostate disease.
New
research finds that the fat surrounding the prostate of overweight or obese men
with prostate cancer provides a favorable environment to promote cancer growth.
Fat
is a generally underrated organ. Not only is it an energy store but it secretes
a wide range of growth factors, cytokines and hormones, including leptin and
adiponectin, and is a major player in the immune system, which protects the
body from infection and disease. But too much fat can cause these systems to go
haywire and can increase risk of diabetes, cardiovascular disease and cancer.
A
team headed by investigators at the ClĂnica Universidad de Navarra (Spain) and
the Portuguese Institute of Oncology compared gene expression in adipose tissue
surrounding the prostate in lean and obese/overweight men with benign prostatic
hyperplasia, or prostate cancer that was either confined to the prostate or had
escaped into the surrounding adipose tissue.
Regardless
of type of prostate disease the overweight men had different levels of gene
activity in the fat surrounding their prostates compared to the lean men. This
included genes which encode proteins involved in immunity and inflammation, and
cell growth and proliferation, fat metabolism
and programmed cell death.
Additionally
the activity of more genes was altered between hyperplasia and prostate cancer,
and between cancer and non-confined cancer, suggesting a gradual increase in
dysregulation during cancer progression.
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The
above story is based on materials provided by BioMed Central Limited.
The
authors report their results in BioMed Central’s open access journal BMC
Medicine:
Ribeiro
R et al. Obesity and prostate cancer:
gene expression signature of human periprostatic adipose tissue. BMC Medicine, 2012; (in Press)
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