Credit: www.glaucoma.org |
Ophthalmic
medications are used for a number of conditions such as glaucoma, infection, allergy
and inflammation, often on a chronic basis. Generally the drugs used in this
manner have good safety profiles, but they do have the potential to cause
significant adverse drug events, and can interact with other systemic
medications.
Ophthalmic
medications pass through the lacrimal sac and have access to the highly
vascular nasal mucosa.
Because
they avoid first-pass metabolism by the liver the pressure lowering side effect
of a single drop of an ophthalmic medication is magnified 10 times when
absorbed through the lacrimal sac.
Here's what you can do to prevent systemic absorption from your eye drops
The systemic absorption of ophthalmic medication
can be minimised using the “double DOT” technique (Don’t Open Eyes Technique
and Digital Occlusion of the Tear duct). This involves closing the eyes and
applying pressure with the finger over the lacrimal sac (outside corner of the
eye) for 1-2 minutes. This can reduce systemic absorption by up to 70%, thus
decreasing the likelihood of significant systemic absorption.
Recommended Robbo, the pharmacist in the great Australian bush.
Health professionals can get more information on the systemic effects of ophthalmic medications from this bulletin by the Repatriation Hospital of South Australia, available via Robbo's bitethedust
Some examples of the ophthalmic medications that can cause systemic side effects |
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