The observation that the Maoris in New Zealand who regularly consumed Perna canaliculus (green-lipped mussel, GLM) suffered less arthritis than their inland relatives, led to the development of a GLM extract in 1974 that has proven benefits as a natural anti-inflammatory to help reduce joint pain and swelling.
There are many mechanisms in the body involved in the inflammatory response. GLM may help to reduce inflammation and swelling by inhibiting the action of one of the enzymes involved in the inflammatory pathway called the lipooxygenase (LOX) pathway. By inhibiting this enzyme, GLM oil can reduce both inflammation and pain.
GLM oil has a more complex lipid structure compared to other marine oils. This includes the presence of a number of compounds known to be anti-inflammatory, such as omega-3 fatty acids. A recent report has confirmed the presence of furan fatty acids (F-acids) which is more effective than EPA.
This complex mixture of lipids is regarded as being essential to explaining the potent action of GLM oil.
S. Brien, et al. Systematic review of the nutritional supplement Perna canaliculus (green-lipped mussel) in the treatment of osteoarthritis. QJM (2008) 101 (3): 167-179.
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Wakimoto T, Kondo H, Nii H, Kimura K, Egami Y, Oka Y, Yoshida M, Kida E, Ye Y, Akahoshi S, Asakawa T, Matsumura K, Ishida H, Nukaya H, Tsuji K, Kan T, Abe I. Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17533-7