 |
| Credit: www.daily-diabetic.com |
Skin Disease Shares
Common Inflammatory Pathway with Metabolic Disorder
Psoriasis is an independent risk for Type 2 Diabetes,
according to a new study by researchers with the Perelman School of Medicine at
the University of
Pennsylvania, with the
greatest risk seen in patients with severe psoriasis. Researchers estimate that
an additional 115,500 people will develop diabetes each year due to the risk
posed by psoriasis above and beyond conventional risk factors. The research is
published in the latest issue of the Archives of Dermatology, a JAMA Network
publication.
"These data suggest that patients with psoriasis are at
increased risk for developing diabetes even if they don't have common risk
factors such as obesity," said senior author Joel M. Gelfand, MD, MSCE,
associate professor of Dermatology in the Perelman School of Medicine.
"Patients with psoriasis should eat a healthy diet, get regular exercise,
and see their physician for routine preventative health screenings such as
checks of blood pressure, cholesterol, and blood sugar."
Psoriasis is a common inflammatory skin disease affecting
over 7.5 million Americans and causes thick, inflamed, scaly patches of skin.
The disease has previously been associated with increased risk of myocardial
infarction, stroke, metabolic syndrome and cardiovascular mortality.
This research builds on previous work demonstrating a
diverse set of increased health risks for people with psoriasis," said
lead author Rahat S. Azfar, MD, MSCE, adjunct assistant professor of
Dermatology in the Perelman School of Medicine. "In addition to having an
increased risk of diabetes, people with psoriasis are more likely to have
metabolic syndrome, high triglycerides, and raised glucose levels, even if they
are not overweight or have other common risk factors for these conditions. Both
patients with psoriasis, especially those with severe psoriasis, and their
treating physicians should be aware of the potential for systemic metabolic
complications associated with this skin disease.
Both psoriasis and diabetes are diseases caused by chronic
inflammation. A shared pathway — TH-1 cytokines — can promote insulin
resistance and metabolic syndrome, and promote inflammatory cytokines known to
drive psoriasis.
The study compared 108,132 people with psoriasis to 430,716
matched patients without psoriasis, and determined patients with mild psoriasis
had an 11% increased risk of diabetes and patients with severe psoriasis had a
46% higher risk compared to patients without psoriasis. The study also looked
at treatments used by those diagnosed with diabetes, and found that the
patients with both psoriasis and diabetes were more likely to require
pharmacological treatment of diabetes, compared to diabetics without psoriasis.
Researchers noted that future studies should look into the
extent to which psoriasis and its treatment play a role in the development of
Type 2 Diabetes and its complications.
###
The above story is based on the
June 18, 2012 news release by University of Pennsylvania School of
Medicine.
The research is published in the latest issue of the
Archives of Dermatology, a JAMA Network publication:
Nicole M. Seminara. Increased Risk of Diabetes
Mellitus and Likelihood of Receiving Diabetes Mellitus Treatment in Patients
With PsoriasisDiabetes Mellitus and Psoriasis. Arch
Dermatol, 2012; : 1 DOI: 10.1001/archdermatol.2012.1401
I am suffering form skin related problems such as psoriasis, its hard to take care I am taking medication tazorac cream to cure it. I found your article very informative in terms of psoriasis and diabetes. really helpful thanks.
ReplyDelete