Diet is considered one of the most important controllable risk factors for inflammation and prostate diseases including benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer (PC). Robert Ma and Kathy Chapman in Sydney, Australia conducted an evidence-based review of dietary recommendations in the prevention of prostate cancer as well as in the management of patients with PC.
The researchers found that a diet low in fat, high in vegetables and fruit, and avoiding high energy intake, excessive meat, and excessive dairy products and calcium intake may be helpful in preventing PC, and for patients diagnosed with PC.
Specifically, consumption of tomatoes, cauliflower, broccoli, green tea, and vitamins including Vitamin E and selenium seemed to propose a decreased risk of PC. Consumption of highly processed or charcoaled meats, dairy products, and fats seemed to be correlated with PC.
Nuclear factor kappa B (NF-κB) is a protein complex that controls DNA transcription. In a recent study Dr. Sanjay Gupta and his team of post-doctoral fellows provide evidence that a high-fat diet increases the activation of NF-κB and its binding to DNA influence influence tumor progression.
Non-obese NF-κB reporter mice were fed a high fat diet for four, eight, and 12 weeks. Compared with mice fed a regular diet, the high fat diet group had significant increases in prostate weight, and in the prostate expression of markers of oxidative stress (such as NADPH), and inflammation (such as the downstream targets of NF-κB: nitric oxide synthase, and cyclooxygenase [COX-2]) were increased.
These studies provide direct evidence that a high fat diet causes proliferation, inflammation, and oxidative stress that can lead to benign prostatic hyperplasia, prostatitis, and cancer of the prostate, some of the most common disorders affecting adult men.
Journal Reference:
R. W.-L. Ma, K. Chapman. A systematic review of the effect of diet in prostate cancer prevention and treatment. Journal of Human Nutrition and Dietetics, 2009; 22 (3): 187-199
Vykhovanets EV, Shankar E, Vykhovanets OV, Shukla S, Gupta S. High-fat diet increases NF-κB signaling in the prostate of reporter mice. The Prostate, 2010, published ahead of print.
* A healthy diet that may benefit men who want to help prevent prostate cancer or who have already been diagnosed. From The Prostate Cancer Charity, UK.
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